alpha-2B Adrenergic R/ADRA2B: Products

Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.

Showing 1-23 out of 23 alpha-2B Adrenergic R/ADRA2B Products

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Clonidine hydrochloride


alpha2 agonist. Also I1 ligand
06906  
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Atipamezole hydrochloride


Selective alpha2 antagonist
29371  
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Yohimbine hydrochloride


Selective alpha2 antagonist
112717  
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Dihydroergotamine mesylate


Partial alpha agonist. Non-selective
0475 
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Guanabenz acetate


alpha2 agonist. Also I2 selective ligand
08854  
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Imiloxan hydrochloride


Highly selective alpha2B antagonist
0986 
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Medetomidine hydrochloride


Potent, highly selective alpha2 agonist
51601  
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Rauwolscine hydrochloride


alpha2 antagonist
08912  
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Dexmedetomidine hydrochloride


Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 5160)
27493  
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RS 79948 hydrochloride


Potent, selective alpha2 antagonist
09871  
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UK 14,304


alpha2 agonist
04253  
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Agmatine sulfate


alpha2 ligand. Also imidazoline ligand
08421  
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SKF 86466 hydrochloride


Potent and selective alpha2 antagonist
3866 
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Idazoxan hydrochloride


alpha2 antagonist. Also I2 ligand
07932  
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ARC 239 dihydrochloride


alpha2B antagonist
0928 
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Rilmenidine hemifumarate


alpha2 agonist. Also I1 ligand
07901  
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Efaroxan hydrochloride


alpha2 antagonist and I1, I3 ligand
0792 
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Tizanidine hydrochloride


alpha2 agonist
3609 
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Dihydroergocristine mesylate


Partial alpha agonist. Non-selective
0474 
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B-HT 933 dihydrochloride


Selective alpha2 agonist
27581  
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A 80426 mesylate


High affinity alpha2 antagonist. Also 5-HT uptake inhibitor
2341 
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UK 14,304 tartrate


alpha2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
2466 
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Human ADRA2B (NP_000673) VersaClone cDNA

RDC0257 
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