alpha-2B Adrenergic R/ADRA2B: Products

Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.

Showing 1-23 out of 23 alpha-2B Adrenergic R/ADRA2B Products

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Clonidine hydrochloride


α2 agonist. Also I1 ligand
06907
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Yohimbine hydrochloride


Selective α2 antagonist
112718
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Atipamezole hydrochloride


Selective α2 antagonist
29371
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Agmatine sulfate


α2 ligand. Also imidazoline ligand
08421
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Guanabenz acetate


α2 agonist. Also I2 selective ligand
08854
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RS 79948 hydrochloride


Potent, selective α2 antagonist
09872
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Medetomidine hydrochloride


Potent, highly selective α2 agonist
51602
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UK 14,304


α2 agonist
04253
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Dihydroergocristine mesylate


Partial α agonist. Non-selective
0474
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Dihydroergotamine mesylate


Partial α agonist. Non-selective
0475
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Efaroxan hydrochloride


α2 antagonist and I1, I3 ligand
0792
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Idazoxan hydrochloride


α2 antagonist. Also I2 ligand
07932
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Rauwolscine hydrochloride


α2 antagonist
08912
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Imiloxan hydrochloride


Highly selective α2B antagonist
0986
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A 80426 mesylate


High affinity α2 antagonist. Also 5-HT uptake inhibitor
2341
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UK 14,304 tartrate


α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
2466
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Dexmedetomidine hydrochloride


Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
27495
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B-HT 933 dihydrochloride


Selective α2 agonist
27581
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Tizanidine hydrochloride


α2 agonist
3609
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SKF 86466 hydrochloride


Potent and selective α2 antagonist
3866
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Rilmenidine hemifumarate


α2 agonist. Also I1 ligand
07901
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ARC 239 dihydrochloride


α2B antagonist
09281
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Human ADRA2B (NP_000673) VersaClone cDNA

RDC0257 
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