beta-3 Adrenergic R/ADRB3: ProductsADRB3 belongs to the G protein coupled-receptor 1 family of beta adrenergic receptors. Beta-adrenergic receptors, including ADRB3, mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. ADRB3 is involved in the regulation of lipolysis and thermogenesis. A variant of ADRB3 seems to be associated with weight gain (obesity). ADRB3 is also associated with susceptibility to non-insulin-dependent diabetes mellitus.