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cIAP-1/HIAP-2: Products

Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.

Showing 1-13 out of 13 cIAP-1/HIAP-2 Products

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Human cIAP-1/HIAP-2 Antibody

IHC, WBAF818114  
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Human/Mouse cIAP Pan-specific Antibody

SW, WBMAB34006  
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Human cIAP-1/HIAP-2 Antibody

WBMAB818 
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Recombinant Human cIAP-1 (HIAP-2) Protein, CF

 818-IA4  
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Human cIAP-1/HIAP-2 Antibody

IHCMAB8181 
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Proteome Profiler Human Apoptosis Array Kit


Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
ARY00928  
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AZD 5582 dihydrochloride


Dimeric Smac mimetic; potent IAP inhibitor
5141 
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UC 112


IAP and XIAP inhibitor; antitumor
5251 
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AEG 40730 dihydrochloride


IAP antagonist; induces apoptosis
5330 
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Recombinant Human His10-cIAP-1/HIAP-2 Protein, CF

 E3-280 
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Human cIAP-1/HIAP-2 Ubiquitin Ligase Kit

K-260 
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Proteome Profiler Human Ubiquitin Array


Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
ARY027 
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Proteome Profiler Human NFkB Pathway Array Kit


Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
ARY029 
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