Glypican 3: Products

The glypicans (GPC) constitute a family of glycosylphosphatidylinositol (GPI)-anchored, heparan sulfate proteoglycans. Six members of this family have been identified in mammals (GPC1-GPC6). All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine-rich domain (CRD) with 14 invariant cysteine residues, a stalk-like region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site.

Mutations in Glypican 3 cause a rare disorder in humans, Simpson-Golabi-Behmel Syndrome, which is characterized by pre- and postnatal overgrowth of multiple tissues and organs and an increased risk for developing embryonic tumors. These features are also present in the mouse knock-out of Glypican 3 indicating that Glypican 3 regulates cell survival and inhibits cell proliferation during development. Glypican 3 has been implicated in regulating many different signaling pathways including: IGF, FGF, BMP and Wnt. An endoproteolytic processing of Glypican 3 by proprotein convertases is required for the modulation of Wnt signaling. Direct interaction of Glypican 3 with FGF-basic has been observed and is mediated by the heparan sulfate chains.

Showing 1-18 out of 18 Glypican 3 Products

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Recombinant Human Glypican 3 Protein

 2119-GP4  
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Recombinant Human Glypican 3 Protein, CF

 2119-GP/CF4  
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Human Glypican 3 Antibody

CyTOF-ready, Flow, ICC/IF, IHC, WBAF21193  
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Human/Mouse/Rat Glypican 3 Antibody

CyTOF-ready, Flow, ICC/IF, WBMAB21191  
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Human Glypican 3 Quantikine ELISA Kit

ELISADGLY30 
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Human Glypican 3 APC-conjugated Antibody

FlowFAB2119A1  
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Human Glypican 3 PE-conjugated Antibody

FlowFAB2119P 
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Human Glypican 3 Biotinylated Antibody

WBBAF2119 
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Human Glypican 3 DuoSet ELISA

ELISADY21191  
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Human Glypican 3 Alexa Fluor® 488-conjugated Antibody

FlowFAB2119G 
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Human Glypican 3 Alexa Fluor® 700-conjugated Antibody

FlowFAB2119N 
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Recombinant Mouse Glypican 3 Protein, CF

 6938-GP 
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Human Glypican 3 Alexa Fluor® 647-conjugated Antibody

FlowFAB2119R 
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Human Glypican 3 Alexa Fluor® 750-conjugated Antibody

FlowFAB2119S 
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Human Glypican 3 Alexa Fluor® 594-conjugated Antibody

FlowFAB2119T 
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Human Glypican 3 Alexa Fluor® 350-conjugated Antibody

FlowFAB2119U 
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Human Glypican 3 Alexa Fluor® 405-conjugated Antibody

FlowFAB2119V 
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Quantikine Immunoassay Control Set 848 for Human Glypican


For use with catalog number DGLY30
CtrlQC203 
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