mGluR1: Products

Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19-592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33-522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

Showing 1-24 out of 24 mGluR1 Products

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LY 367385


Selective mGlu1a antagonist
123731  
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Human/Mouse/Rat mGluR5/1a Antibody

IHC, WBPPS079 
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JNJ 16259685


Extremely potent, mGlu1-selective non-competitive antagonist
23335  
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Rat mGluR1 C-Terminus Antibody

IHC, WBPPS077 
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CPCCOEt


Selective non-competitive mGlu1 receptor antagonist
102817  
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Bay 36-7620


Non-competitive mGlu1 antagonist with inverse agonist activity
25014  
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Human mGluR1a Antibody

WBAF4836 
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Human mGluR1a Antibody

IHCMAB4836 
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FTIDC


Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist
5000 
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VU 0483605


Positive allosteric modulator at mGlu1
5377 
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YM 298198 hydrochloride


Highly potent, selective non-competitive mGlu1 antagonist
2448 
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YM 230888


Selective mGlu1 antagonist
2986 
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Desmethyl-YM 298198


Derivative of mGlu1 antagonist YM 298198 (Cat. No. 2448)
2447 
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Ro 67-4853


Positive allosteric modulator of group I mGlu receptors
4347 
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CPPHA


Positive allosteric modulator at mGlu1 and mGlu5
4787 
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VU 0469650 hydrochloride


Potent and selective negative allosteric modulator of mGlu1
5379 
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LY 456236 hydrochloride


Selective mGlu1 antagonist
2390 
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YM 202074


High affinity, selective mGlu1 antagonist
3413 
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Ro 67-7476


Positive allosteric modulator of mGlu1
4346 
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3-MATIDA


Potent, selective mGlu1 antagonist
2196 
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AZD 9272


Potent and selective mGlu5 antagonist; brain penetrant
5613 
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A 841720


Selective mGlu1 antagonist
30601  
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Ro 01-6128


Positive allosteric modulator of mGlu1
4348 
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Human mGluR1 (AAB05337) VersaClone cDNA

RDC0983 
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