mGluR5: Products

Human metabotropic glutamate receptor 5 (mGluR5; also mGluR5b) is a 150 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length and contains an extracellular domain (ECD) of 558 amino acids. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca2+-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877 - 908 in the cytoplasmic tail. Over aa 19 - 509, human mGluR5 is 98% aa identical to mouse, rat, and canine mGluR5.

Showing 1-29 out of 29 mGluR5 Products

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MTEP hydrochloride


Potent, selective mGlu5 antagonist
29218  
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CHPG Sodium salt


Selective mGlu5 agonist. Sodium salt of CHPG (Cat. No. 1049)
3695 
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Human mGluR5 Antibody

Flow, WBMAB4514 
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Human/Mouse/Rat mGluR5/1a Antibody

IHC, WBPPS079 
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Human mGluR5 Antibody

IHCMAB451412  
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CHPG


mGlu5 selective agonist
104911  
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CDPPB


Positive allosteric modulator at mGlu5
32352  
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Human mGluR5 Antibody

IHC, WBAF4514 
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VU 0360172 hydrochloride


Positive allosteric modulator at mGlu5
4323 
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Fenobam


Potent and selective mGlu5 antagonist
2386 
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VU 0285683


Negative allosteric modulator at mGlu5
4381 
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VU 0357121


Positive allosteric modulator of mGlu5
4437 
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MFZ 10-7


Negative allosteric modulator at mGlu5
4438 
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DFB


Allosteric potentiator at mGlu5
1625 
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VU 29


Potent mGlu5 allosteric potentiator
44581  
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Ro 67-4853


Positive allosteric modulator of group I mGlu receptors
4347 
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LSN 2463359


Potent and selective positive allosteric modulator at mGlu5
5275 
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ADX 10059 hydrochloride


Negative allosteric modulator at mGlu5
4416 
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CPPHA


Positive allosteric modulator at mGlu1 and mGlu5
4787 
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ACDPP hydrochloride


Selective mGlu5 receptor antagonist
2254 
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ABP 688


High affinity human mGlu5 receptor antagonist
5229 
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DCB


Allosteric modulator at mGlu5
1952 
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VU 0360223


Negative allosteric modulator at mGlu5
4394 
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SIB 1757


Highly selective mGlu5 antagonist
12151  
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VU 1545


mGlu5 positive allosteric modulator
3325 
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DMeOB


Negative allosteric modulator at mGlu5
1953 
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VU 0409551


Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
5693 
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AZD 2066


mGlu5 antagonist; orally bioavailable and brain penetrant
5614 
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Human mGluR5 (NP_000833) VersaClone cDNA

RDC1064 
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