p38: Products

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

Showing 1-26 out of 26 p38 Products

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SB 203580


Selective inhibitor of p38 MAPK
120261  
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SB 202190


Potent, selective inhibitor of p38 MAPK
126418  
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Anisomycin


JNK, SAPK and p38 activator
129010  
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SB 203580 hydrochloride


Selective inhibitor of p38 MAPK; water-soluble
14026  
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SB 239063


Potent, selective p38 MAPK inhibitor; orally active
19624  
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SCIO 469 hydrochloride


Selective p38 MAPK inhibitor
3528 
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SX 011


p38 MAPK inhibitor
3639 
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TA 01


Induces cardiomyocyte differentiation from hESCs
5383 
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RWJ 67657


Potent, selective p38alpha and p38beta inhibitor
2999 
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SKF 86002 dihydrochloride


p38 MAPK inhibitor; anti-inflammatory agent
20081  
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CGH 2466 dihydrochloride


A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
2344 
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SB 706504


p38 MAPK inhibitor
5040 
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DBM 1285 dihydrochloride


p38 MAPK inhibitor; anti-inflammatory
5095 
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VX 745


Potent and selective p38alpha inhibitor
39151  
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JX 401


Potent, reversible p38alpha inhibitor
2657 
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ML 3403


p38 inhibitor
4586 
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EO 1428


Selective inhibitor of p38alpha and p38beta2
2908 
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TA 02


Induces cardiomyocyte differentiation from hESCs
5384 
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TAK 715


Potent p38 MAPK inhibitor; anti-inflammatory
4254 
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CMPD-1


Selective inhibitor of p38alpha-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
21861  
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VX 702


Orally active p38alpha and p38beta inhibitor
39161  
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AMG 548


Potent and selective p38alpha inhibitor
39201  
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BIRB 796


High affinity and selective p38 kinase inhibitor
5989 
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PH 797804


Potent and selective p38alpha/beta inhibitor
5866 
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p38 MAPK Inhibitor Tocriset™


Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)
2244 
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Proteome Profiler Human Cell Stress Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
ARY0182  
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