p38 alpha: Products

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

Showing 1-23 out of 23 p38 alpha Products

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Proteome Profiler Human Phospho-Kinase Array Kit


Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B155  
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Phospho-p38 alpha (T180/Y182) DuoSet IC ELISA

ELISADYC869B-211  
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Human/Mouse/Rat p38 alpha Antibody

IHC, KO, SW, WBAF86913  
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Human Phospho-p38 alpha (T180/Y182) Antibody

WBMAB86913  
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Proteome Profiler Human Phospho-MAPK Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different MAPK antibodies
ARY002B79  
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Human/Mouse/Rat p38 alpha Antibody

KO, WBMAB8691  
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Total p38 alpha DuoSet IC ELISA

ELISADYC8691B-21  
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Human Phospho-p38 alpha (T180/Y182) Antibody

ICC/IFMAB8692 
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Recombinant Human Active p38 alpha Protein, CF

Bioactivity5477-KS 
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CMPD-1


Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
21862
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JX 401


Potent, reversible p38α inhibitor
2657
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EO 1428


Selective inhibitor of p38α and p38β2
2908
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RWJ 67657


Potent, selective p38α and p38β inhibitor
2999
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VX 745


Potent and selective p38α inhibitor
39151
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VX 702


Orally active p38α and p38β inhibitor
39162
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AMG 548


Potent and selective p38α inhibitor
39201
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ML 3403


p38 inhibitor
4586
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AL 8697


Potent and selective p38α inhibitor
4753
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AZ 12080282 dihydrochloride


Inhibitor of Hedgehog (Hh) signaling
4838
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SB 706504


p38 MAPK inhibitor
5040
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DBM 1285 dihydrochloride


p38 MAPK inhibitor; anti-inflammatory
5095
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PH 797804


Potent and selective p38α/β inhibitor
5866
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Org 48762-0


Selective p38α/β inhibitor; orally bioavailable
6014
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