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p53: Products

p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat orthologs, respectively. Mutations in the p53 gene are one of the most frequent genomic events accompanying oncogenic transformation. p53 responds to signals such as DNA damage or cell stress primarily through its actions as a transcription factor. Among its gene targets are a range factors that promote DNA repair mechanisms or apoptosis including cell cycle regulatory proteins and members the Bcl-2 family. Because of its critical role in genomic homeostasis, p53 activities are tightly regulated by a network of protein-protein interactions, microRNAs, and a range of post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination. A widely studied regulator is Murine Double Minute 2 (MDM2). MDM2 is known to suppress p53 activity through direct binding or through its actions as a Ubiquitin ligase (E3) that catalyzes p53 ubiquitination and proteasome-mediated degradation.

Showing 1-50 out of 75 p53 Products

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Human/Mouse/Rat p53 Antibody

ChIP, ICC/IF, IP, KO, SW, WBAF13556  
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Proteome Profiler Human Phospho-Kinase Array Kit


Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B130  
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Human/Mouse/Rat p53 Antibody

ICC/IF, IP, WBMAB13554  
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Human Phospho-p53 (S15) Antibody

ICC/IF, IHC, IP, WBAF10433  
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Human/Mouse/Rat p53 HRP-conjugated Antibody

WBHAF13556  
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Human Phospho-p53 (S46) Antibody

IHC, SW, WBAF14891  
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Recombinant Human His6-p53 Protein, CF

 SP-450 
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Human Total p53 DuoSet IC ELISA

ELISADYC1043-22  
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Proteome Profiler Human Phospho-MAPK Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different MAPK antibodies
ARY002B70  
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Human/Mouse/Rat p53 Biotinylated Antibody

WBBAF13552  
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Human Phospho-p53 (S15) Antibody

CyTOF-ready, Flow, WBMAB1839 
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Recombinant Human p53 Protein, CF

 SP-4541  
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Human Phospho-p53 (S392) Antibody

SW, WBAF2996 
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Mouse p53 Antibody

IPMAB17462  
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Human Phospho-p53 (S392) Antibody

ICC/IF, WBMAB2996 
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PRIMA-1MET


Restores mutant p53 activity
37101  
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Human Phospho-p53 (S37) Antibody

WBAF3306 
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Human Phospho-p53 (S15) DuoSet IC ELISA

ELISADYC1839-22  
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Human/Mouse/Rat p53 Agarose-conjugated Antibody

IPGAF13551  
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Human Phospho-p53 (S46) Antibody


Recombinant Monoclonal Antibody.
WBMAB1489 
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Human Phospho-p53 (S15) Antibody

CyTOF-ready, Flow, ICC/IFMAB18391 
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Proteome Profiler Human Apoptosis Array Kit


Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
ARY00945  
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Pifithrin-α hydrobromide


p53 inhibitor. Also aryl hydrocarbon receptor agonist
12672  
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RITA


MDM2-p53 interaction inhibitor
24431  
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Pifithrin-μ


Inhibitor of p53-mitochondrial binding
26534  
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Nutlin-3


MDM2 antagonist; inhibits MDM2-p53 interaction
39841  
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Human p53 APC-conjugated Antibody

FlowIC13551A 
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Phospho-p53 (S15) PE-conjugated Antibody

FlowIC1839P 
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Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

K-200B 
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Human p53 Antibody

CyTOF-ready, FlowMAB13551 
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Recombinant Human His6-FLAG-p53 Protein, CF

SP-452 
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PRIMA-1


Restores mutant p53 activity; induces apoptosis
18622  
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NSC 146109 hydrochloride


Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
2185 
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NSC 66811


MDM2 antagonist. Disrupts MDM2-p53 interaction
2936 
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CP 31398 dihydrochloride


p53-stabilizing agent
30232  
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RETRA hydrochloride


Antitumor agent; suppresses mutant p53-bearing cancer cells
3214 
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WR 1065


p53 activator. Also ROS scavenger
3356 
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MG 101


Calpain inhibitor; activates p53-dependent apoptosis
33581  
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MIRA-1


Restores mutant p53 activity; proapoptotic
3362 
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Tenovin-1


Protects against MDM2-mediated p53 degradation
3365 
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HLI 373


Hdm2 inhibitor; activates p53-dependent transcription
3503 
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Cyclic Pifithrin-α hydrobromide


p53 inhibitor
3843 
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SJ 172550


MDMX inhibitor. Disrupts MDMX-p53 interaction
3929 
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SCH 529074


Restores mutant p53 activity
4240 
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PhiKan 083


p53 stabilizing agent
4326 
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Piperlongumine


Induces apoptosis; increases p53 and ROS levels in cancer cells
43961  
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SP 141


High affinity MDM2 inhibitor
5332 
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BMH 21


RNA polymerase 1 inhibitor; also p53 pathway activator
5417 
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Human Phospho-p53 (S392) DuoSet IC ELISA

ELISADYC2996-2 
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Human p53 Alexa Fluor® 488-conjugated Antibody

FlowIC13551G 
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