p53: Products

p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat orthologs, respectively. Mutations in the p53 gene are one of the most frequent genomic events accompanying oncogenic transformation. p53 responds to signals such as DNA damage or cell stress primarily through its actions as a transcription factor. Among its gene targets are a range factors that promote DNA repair mechanisms or apoptosis including cell cycle regulatory proteins and members the Bcl-2 family. Because of its critical role in genomic homeostasis, p53 activities are tightly regulated by a network of protein-protein interactions, microRNAs, and a range of post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination. A widely studied regulator is Murine Double Minute 2 (MDM2). MDM2 is known to suppress p53 activity through direct binding or through its actions as a Ubiquitin ligase (E3) that catalyzes p53 ubiquitination and proteasome-mediated degradation.

Showing 1-16 out of 16 p53 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Human Phospho-p53 (S46) Antibody


Recombinant Monoclonal Antibody.
WBMAB1489 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat p53 Antibody

ChIP, ICC/IF, IP, SW, WBAF13554  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat p53 Antibody

ICC/IF, IP, WBMAB13554  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S15) Antibody

ICC/IF, IHC, IP, WBAF10432  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat p53 HRP-conjugated Antibody

WBHAF13556  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S46) Antibody

IHC, SW, WBAF14891  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S15) Antibody

CyTOF-ready, Flow, WBMAB1839 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat p53 Biotinylated Antibody

WBBAF13552  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S392) Antibody

SW, WBAF2996 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse p53 Antibody

IPMAB17462  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S37) Antibody

WBAF3306 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human Phospho-p53 (S15) Antibody

CyTOF-ready, Flow, ICC/IFMAB18391 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human/Mouse/Rat p53 Agarose-conjugated Antibody

IPGAF13551  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Phospho-p53 (S15) PE-conjugated Antibody

FlowIC1839P 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human p53 APC-conjugated Antibody

FlowIC13551A 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human p53 Antibody

CyTOF-ready, FlowMAB13551 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page