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p53: Products

p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat orthologs, respectively. Mutations in the p53 gene are one of the most frequent genomic events accompanying oncogenic transformation. p53 responds to signals such as DNA damage or cell stress primarily through its actions as a transcription factor. Among its gene targets are a range factors that promote DNA repair mechanisms or apoptosis including cell cycle regulatory proteins and members the Bcl-2 family. Because of its critical role in genomic homeostasis, p53 activities are tightly regulated by a network of protein-protein interactions, microRNAs, and a range of post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination. A widely studied regulator is Murine Double Minute 2 (MDM2). MDM2 is known to suppress p53 activity through direct binding or through its actions as a Ubiquitin ligase (E3) that catalyzes p53 ubiquitination and proteasome-mediated degradation.
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Human/Mouse/Rat p53 Antibody

(1 Review)
3 Citations
Clonality: Polyclonal
Host: Goat IgG
Applications: ChIP, ICC/IF, IP, Simple Western, WB
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AF1355

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Human/Mouse/Rat p53 Antibody Western Blot
Human/Mouse/Rat p53 Antibody Simple Western
Human/Mouse/Rat p53 Antibody Chromatin Immunoprecipitation (ChIP)
Human/Mouse/Rat p53 Antibody Immunocytochemistry

Human Phospho-p53 (S15) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: ICC/IF, IHC, IP, WB
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AF1043

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Human Phospho-p53 (S15) Antibody Western Blot
Human Phospho-p53 (S15) Antibody Immunohistochemistry
Human Phospho-p53 (S15) Antibody Immunohistochemistry
Human Phospho-p53 (S15) Antibody Immunocytochemistry

Human Phospho-p53 (S46) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: IHC, Simple Western, WB
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AF1489

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Human Phospho-p53 (S46) Antibody Western Blot
Human Phospho-p53 (S46) Antibody Simple Western
Human Phospho-p53 (S46) Antibody Immunohistochemistry
Human Phospho-p53 (S46) Antibody Immunohistochemistry

Human/Mouse/Rat p53 Antibody

Clonality: Monoclonal
Host: Mouse IgG2b Clone #184721
Applications: ICC/IF, IP, WB
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MAB1355

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Human/Mouse/Rat p53 Antibody Western Blot
Human/Mouse/Rat p53 Antibody Immunocytochemistry

Human Phospho-p53 (S392) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: Simple Western, WB
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AF2996

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Human Phospho-p53 (S392) Antibody Western Blot
Human Phospho-p53 (S392) Antibody Simple Western

Mouse p53 Antibody

Clonality: Monoclonal
Host: Rat IgG2b Clone #197643
Applications: IP
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MAB1746

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Mouse p53 Antibody Immunoprecipitation

Human Phospho-p53 (S15) Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #261352
Applications: Flow, WB
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MAB1839

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Human Phospho-p53 (S15) Antibody Western Blot
Human Phospho-p53 (S15) Antibody Intracellular Staining by Flow Cytometry

Human Phospho-p53 (S15) Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #261366
Applications: Flow, ICC/IF
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MAB18391

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Human Phospho-p53 (S15) Antibody Intracellular Staining by Flow Cytometry

Human Phospho-p53 (S37) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: WB
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AF3306

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Human Phospho-p53 (S37) Antibody Western Blot

Mouse Phospho-p53 (S18) Antibody

Clonality: Polyclonal
Host: Rabbit IgG
Applications: WB
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AF2887

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Mouse Phospho-p53 (S18) Antibody Western Blot
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