sFRP-1 (Secreted Frizzled Related Protein-1), also known as SARP-2, FRP, and FrzA, is a secreted protein that binds to Wnt-1, -2, -3a, and -4 and prevents their activation of canonical beta-Catenin signaling. sFRP-1 is upregulated in the ischemic heart where it limits inflammation and the severity of tissue damage following myocardial infarction. During angiogenesis it induces endothelial cell migration, tube formation, and vessel formation. sFRP-1 is expressed by bone marrow stromal cells and osteoclasts. It binds to TRANCE/RANK Ligand, inhibits osteoclast and osteoblast formation and survival, and inhibits the formation of trabecular bone. sFRP-1 additionally restricts kidney tubule formation, the inflammatory activation of leukocytes, early B lymphoid progression, and vitreous fluid outflow in the eye.