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EGF R/ErbB1: Products

EGF R (epidermal growth factor receptor), also known as HER-1, ErbB1, or ErbB, is a transmembrane receptor tyrosine kinase that binds a subset of the EGF family ligands including EGF, Amphiregulin, TGF-alpha, Betacellulin, Epiregulin, HB-EGF, and Epigen. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGF R is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse.

Showing 1-50 out of 71 EGF R/ErbB1 Products

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Recombinant Monoclonal Antibody.
ICC/IF, SW, WBMAB8967 
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LXSAMSM 
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 344-ER2  
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ELISA(Cap), Flow, IP, WBAF2315  
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 1095-ER3  
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Flow, ICC/IF, IHC, SW, WBAF10952  
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Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
ARY003B66  
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Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B93  
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ELISADYC1095B-210  
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IHC, SW, WBAF12801  
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ELISA(Det), Flow, WBBAF2313  
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ELISADEGFR02  
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WBMAB10956  
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LXSAMS 
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ELISADYC1854-26  
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Flow, ICC/IF, IHC, WBAF33941  
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Flow, WBMAB35702  
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ICC/IF, SW, WBMAB8336 
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ICC/IF, SW, WBMAB89671 
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Orally active, selective EGFR inhibitor
3000 
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ICC/IF, WBMAB8274 
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ELISADYC3570-23  
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ICC/IF, WBMAB8130 
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IHC, WBBAF1280 
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FlowFAB10951P1  
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EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
0414 
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WBMAB8058 
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FlowFAB10951F1  
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 1280-ER1  
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ELISADY2312  
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ELISAMEGFR0 
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ELISAKCB10952  
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Potent ErbB receptor family inhibitor
2615 
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Highly potent EGFR-kinase inhibitor
1276 
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EGFR kinase inhibitor. Also estrogen and PPARgamma ligand
1110 
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Highly selective EGFR-kinase inhibitor
2416 
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FlowIC3570F 
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FlowFAB10951R 
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FlowFAB10951A 
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FlowIC3570P 
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FlowMAB10951 
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FlowFAB10951G 
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Potent EGFR and VEGFR inhibitor
5318 
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Potent EGFR-kinase inhibitor
4941 
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Potent EGFR-kinase inhibitor
0618 
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Potent inhibitor of the ErbB receptor family
2646 
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EGFR-kinase inhibitor
0577 
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Potent EGFR-kinase inhibitor
0619 
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EGFR/PDGFR-kinase inhibitor
0493 
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Selective inhibitor of EGFR-kinase
2417 
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