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Endogenous 5-HT receptor agonist
Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
Potent and selective 5-HT7 antagonist; brain penetrant
5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
α partial agonist; also D2-like partial agonist and 5-HT antagonist
D2-like antagonist; also high affinity 5-HT7 antagonist
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
Selective 5-HT7 antagonist
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
High affinity and selective 5-HT7 antagonist; orally bioavailable