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mRNA splicing inhibitor; antitumor
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Cytotoxic nucleoside analog; inhibits RNA synthesis
Potent and selective Cdc7 inhibitor
Arrests cell cycle in G1 phase
5- and 12-Lipoxygenase inhibitor
GSK-3β inhibitor; also inhibits cdks and other protein kinases
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest
Inhibits c-Myc-Max dimerization
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
BET bromodomain inhibitor; arrests cell cycle at G1 phase
Potent and selective mTOR inhibitor
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
Potent and selective CDK7 inhibitor; induces cell cycle arrest
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
Allosteric activator of protein phosphatase 2A (PP2A)
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor