Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 67 results in Products.
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DMSO, sterile filtered 

DMSO, sterile filtered, wide ranging applications in cell culture, cryopreservation and organic chemistry. Solvent for polar and nonpolar compounds


Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

LDN 193189 dihydrochloride 

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs


Adenylyl cyclase activator


Selective ALK2 inhibitor

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor


Forskolin synthesized to Ancillary Material Grade


DAPT synthesized to Ancillary Material Grade


PDE inhibitor (non-selective)


High affinity PKC activator; also APP modulator

Retinoic acid 

Endogenous retinoic acid receptor agonist

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent


Anti-inflammatory glucocorticoid

2-Phospho-L-ascorbic acid trisodium salt 

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2


Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells

A 769662 

Potent AMPK activator


Smo receptor agonist

CKI 7 dihydrochloride 

CK1 inhibitor

Fluoxetine hydrochloride 

5-HT reuptake inhibitor


AMPK activator

SP 600125 

Selective JNK inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

Sodium butyrate 

Histone deacetylase inhibitor


Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

PD 173074 

FGFR1 and -3 inhibitor

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

Erlotinib Hydrochloride 

Potent, reversible EGFR tyrosine kinase inhibitor

LDN 193189 

LDN 193189 synthesized to cGMP guidelines


DNA methyltransferase inhibitor

EC 23 

Synthetic retinoid; induces differentiation of stem cells

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

CHIR 98014 

Highly potent and selective GSK-3 inhibitor

DMSO, Cell Cryopreserve Grade 

Intracellular cryoprotective agent

A 83-01 

A 83-01 synthesized to Ancillary Material Grade


DNA methyltransferase and cytidine deaminase inhibitor

Thioridazine hydrochloride 

Dopamine receptor antagonist; antipsychotic


Induces neurogenesis in mature skeletal muscle cells


Potently induces chondrogenesis in MSCs

A 939572 

Potent SCD-1 inhibitor

PluriSln 1 

SCD-1 inhibitor

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors


Selective inducer of neuronal differentiation in hippocampal neural progenitors

CCG 1423 

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

FH 1 

Enhances iPSC-derived hepatocyte differentiation and maturation


Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

CW 008 

PKA signaling activator; promotes osteogenesis from hMSCs

SW 033291 

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
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