Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 65 results in Products.
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DAPT 

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

LDN 193189 dihydrochloride 

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Forskolin 

Adenylyl cyclase activator

DMSO, sterile filtered 

DMSO, sterile filtered, wide ranging applications in cell culture, cryopreservation and organic chemistry. Solvent for polar and nonpolar compounds

TPPB 

High affinity PKC activator; also APP modulator

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor

DMH-1 

Selective ALK2 inhibitor

Retinoic acid 

Endogenous retinoic acid receptor agonist

IBMX 

PDE inhibitor (non-selective)

Dexamethasone 

Anti-inflammatory glucocorticoid

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2

AICAR 

AMPK activator

T3 

Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

Purmorphamine 

Smo receptor agonist

Fluoxetine hydrochloride 

5-HT reuptake inhibitor

SP 600125 

Selective JNK inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

PD 173074 

FGFR1 and -3 inhibitor

Sodium butyrate 

Histone deacetylase inhibitor

A 769662 

Potent AMPK activator

5-Azacytidine 

DNA methyltransferase inhibitor

2-Phospho-L-ascorbic acid trisodium salt 

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

CHIR 98014 

Highly potent and selective GSK-3 inhibitor

DAPT 

DAPT synthesized to Ancillary Material Grade

EC 23 

Synthetic retinoid; induces differentiation of stem cells

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

AS 1842856 

Potent and selective Foxo1 inhibitor; orally bioavailable

BOP 

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Pyridone 6 

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

T3 

T3 synthesized to Ancillary Material Grade

Zebularine 

DNA methyltransferase and cytidine deaminase inhibitor

Thioridazine hydrochloride 

Dopamine receptor antagonist; antipsychotic

Neurodazine 

Induces neurogenesis in mature skeletal muscle cells

TCS 2210 

Inducer of neuronal differentiation in MSCs

Kartogenin 

Potently induces chondrogenesis in MSCs

A 939572 

Potent SCD-1 inhibitor

PluriSln 1 

SCD-1 inhibitor

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Neuropathiazol 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

CCG 1423 

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

FH 1 

Enhances iPSC-derived hepatocyte differentiation and maturation

SIS3 

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

CKI 7 dihydrochloride 

CK1 inhibitor

CW 008 

PKA signaling activator; promotes osteogenesis from hMSCs

SW 033291 

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

WHI-P 154 

JAK3 kinase inhibitor. Also inhibits EGFR

P7C3 

NAMPT activator; also proneurogenic and neuroprotective
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