Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 32 results in Products.
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DAPT 

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

LDN 193189 dihydrochloride 

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Forskolin 

Adenylyl cyclase activator

DMSO, sterile filtered 

DMSO, sterile filtered, wide ranging applications in cell culture, cryopreservation and organic chemistry. Solvent for polar and nonpolar compounds

TPPB 

High affinity PKC activator; also APP modulator

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor

DMH-1 

Selective ALK2 inhibitor

Retinoic acid 

Endogenous retinoic acid receptor agonist

IBMX 

PDE inhibitor (non-selective)

Dexamethasone 

Anti-inflammatory glucocorticoid

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2

AICAR 

AMPK activator

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

Purmorphamine 

Smo receptor agonist

Fluoxetine hydrochloride 

5-HT reuptake inhibitor

SP 600125 

Selective JNK inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

PD 173074 

FGFR1 and -3 inhibitor

A 769662 

Potent AMPK activator

5-Azacytidine 

DNA methyltransferase inhibitor

EC 23 

Synthetic retinoid; induces differentiation of stem cells

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

BOP 

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Zebularine 

DNA methyltransferase and cytidine deaminase inhibitor

Thioridazine hydrochloride 

Dopamine receptor antagonist; antipsychotic

TCS 2210 

Inducer of neuronal differentiation in MSCs

A 939572 

Potent SCD-1 inhibitor

ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

SIS3 

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

ISX 9 

ISX 9 synthesized to Ancillary Material Grade
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