Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 65 results in Products.
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KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Lin28 1632 

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Phenanthroline 

Enhances hPSC differentiation into cranial placode cells

Sodium Cromoglicate 

Promotes ESCs/iPSCs differentiation into pancreatic endocrine islet cells

FM19G11 

HIF α-subunit inhibitor

DC 271 

Fluorescent retinoic acid analog; solvochromatic probe

JNJ 10198409 

Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

RCGD 423 

gp130 modulator; activates JAK/STAT signaling

Erlotinib Hydrochloride 

Potent, reversible EGFR tyrosine kinase inhibitor

TWS 119 

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

DMSO, Cell Cryopreserve Grade 

Intracellular cryoprotective agent

Forskolin 

Forskolin synthesized to Ancillary Material Grade

A 83-01 

A 83-01 synthesized to Ancillary Material Grade

ISX 9 

ISX 9 synthesized to Ancillary Material Grade

LDN 193189 

LDN 193189 synthesized to cGMP guidelines
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