CXCR5, also known as Burkitt Lymphoma Receptor 1, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR5 is 372 amino acids (aa) in length with a predicted molecular weight of 42 kDa. Mouse and rat CXCR5 share 83% and 81% aa sequence identity with the human protein, respectively. CXCR5 is primarily expressed on B cells and binds CXCL13/BCL/BCA-1. The CXCL13/BCL/BCA-1:CXCR5 axis regulates B cell migration within secondary lymphoid organs such as the spleen and Peyer’s patches. CXCR5 is also expressed on follicular helper T cells and dermal-derived migratory dendritic cells where it is thought to promote the humeral immune response by meditating germinal center reactions and B cell activation. Polymorphisms of CXCR5 are associated with multiple types of non-Hodgkin’s lymphoma, and it is expressed on Burkitt’s lymphoma cells.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.