Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Cartridges below are for plasma/serum (PS-000496) cartridges. Stocked cartridges are indicated with ST01 and available to ship in 3-4 days. Simple Plex Human Granzyme B assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and was
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