IL-3 R beta: Products

Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R.

IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL-3 R beta chain has a very large cytoplasmic domain. Recent studies suggest that formation of IL-3 R beta-beta homodimers initiates signaling events. The IL-3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes.

"IL-3 R beta" has 15 results in Products.
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Mouse IL-3 R beta Antibody

1 Image
B/N, CyTOF-ready, Flow, WB

Mouse IL-3 R beta Biotinylated Antibody

ELISA(Det), Flow, WB

Mouse IL-3 R beta Antibody

WB

Mouse IL-3 R beta Antibody

ELISA(Cap)

Mouse IL-3 R beta Antibody

Flow
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