IRF4: Products

Interferon regulator transcription factors (IRF) are a family characterized by a helix-turn-helix DNA binding domain enriched in tryptophan repeats.

Interferon regulatory factor 4 (IRF4), also known as MUM1 and LSIRF, is a 51 kDa lymphocyte-restricted transcription factor. It is required for immunoglobulin class switching and terminal differentiation of B cells. IRF4 is overexpressed in multiple myeloma and cooperates with Myc in an autoregulatory loop. In T cells, IRF4 is required for the production of IL-4. IRF4 contains an N-terminal DNA binding domain that is homolgous to that in other IRF proteins. Within the C-terminal domain (aa 130 - 451), human IRF4 shares 90% aa sequence identity with mouse and rat IRF4. Alternate splicing may generate isoforms with N-terminal, C-terminal, or internal deletions.

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Human IRF4 Antibody 

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