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NAMPT Inhibitors

Nicotinamide phosphoribosyltransferase (NAMPT), EC 2.4.2.12, is an enzyme that catalyzes the transfer of a phosphoribosyl group to nicotinamide (NAM), forming nicotinamide mononucleotide (NMN), which is then converted to nicotinamide adenine dinucleotide (NAD). The formation of NMN is the rate limiting step for the synthesis of NAD, an important intermediate of cell metabolism and redox reactions. Next NAD-dependent enzymes, such as poly (ADP-ribose) polymerase (PARP) and sirtuins, catalyze ...

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NAMPT PROTAC® A7
Catalog #: 7842
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Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)
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