PA28 Activator gamma Subunit: Products

The Proteasome Activator 28 (PA28) Regulatory Complex, also known as the 11S Regulatory (REG) Complex, is a ring-shaped, multimeric, ATP-independent regulatory complex that can bind to one or both ends of the 20S Proteasome or 20S Immunoproteasome.

The human PA28 Activator gamma Subunit, also known as 11S REG gamma and Ki antigen, is a 254 amino acid (aa) member of the PA28 family of regulatory proteins with a predicted molecular weight of 29 kDa. The mouse and rat orthologs share 100% aa sequence identity with human PA28 gamma. Two isoforms of PA28 gamma have been identified. Six PA28 gamma subunits combine to form a homo-hexameric ring-shaped PA28 Regulatory Complex. Unlike PA28 Regulatory Complexes composed of PA28 alpha subunits or PA28 alpha/beta subunits, regulatory complexes composed of PA28 gamma subunits have narrow substrate specificity and have been shown to cleave only a few biologically relevant protein substrates. PA28 gamma is involved in cell cycle progression and in T cell-restricted MHC class I presentation of select antigens.

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