PCPE-1: Products

Collagen maturation includes the processing of N- and C-propeptides by Procollagen N- and C-proteinases encoded by the ADAMTS2 and BMP-1 genes, respectively. PCPE (Procollagen C-proteinase Enhancer) binds to either side of the C-propeptide cleavage site, thereby facilitating the Procollagen C-proteinase activity of BMP1. PCPE does not enhance the chordinase activity of BMP-1.