SLC6A3/DAT1: Products

The dopamine transporter (DAT) is a 70 - 80 kDa member of the Na+-neurotransmitter symporter family of transmembrane (TM) proteins. DAT plays a crucial role in the synaptic clearance of dopamine (DA).

The human dopamine transporter is a 620 amino acid (aa), 12 TM phosphoglycoprotein with an N- and C-terminal cytoplasmic domain. Human DAT exists as a disulfide-linked oligomer on the cell surface. Phosphorylation of the N-terminus (S7/12) promotes DA release. The C-terminus binds CaMKII, as well as Hic5, Pick1, and synuclein which regulate receptor trafficking and expression. There is an extended 71 aa extracellular (EC) loop between TM segments 3 and 4. Glycosylation at this site is necessary for oligomer expression on the cell membrane. The human 42 aa DAT C-terminus is 93% aa identical to the mouse DAT C-terminus. The human EC loop is also 93% aa identical to the rhesus monkey EC loop.

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GBR 12909 dihydrochloride 

Selective DA uptake inhibitor; also σ ligand
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