TRAIL R1/TNFRSF10A: Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.

"TRAIL R1/TNFRSF10A" has 19 results in Products.
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Recombinant Human TRAIL R1/TNFRSF10A Fc Chimera Protein

A New rh TRAIL R1 is Now Available! ~2 fold better activity; CHO expressed; No his tag!
Bioactivity
Newer Version Available: 6949-DR-100

Recombinant Human TRAIL R1/TNFRSF10A Fc Chimera Protein, CF

A New rh TRAIL R1 is Now Available! ~2 fold better activity; CHO expressed; No his tag!
Bioactivity
Newer Version Available: 6949-DR-100

Proteome Profiler Human Apoptosis Array Kit

Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies

Proteome Profiler Human NFkB Pathway Array

Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
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