AMG 853

Tocris Bioscience | Catalog # 5701

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
Tocris Bioscience
Discontinued Product
5701 has been discontinued. View all Prostanoid Receptor Antagonists products.

Key Product Details

Description

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
View all Prostanoid Receptor Antagonists »

Product Description

AMG 853 is a potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.

Product Specifications for AMG 853

Molecular Weight

609.49

Formula

C28H27Cl2FN2O6S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneacetic acid

CAS Number

1169483-24-2

PubChem ID

42641863

InChI Key

PFWVGKROPKKEDW-UHFFFAOYSA-N

SMILES

ClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.95 100
Ethanol 60.95 100

Preparing Stock Solutions for AMG 853

The following data is based on the product molecular weight 609.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.20 mL 16.41 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AMG 853

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMG 853

For research use only

Customer Reviews for AMG 853 (1)

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  • AMG 853 blocks p38 phosphorylation in 15d-PGJ2 treated cardiomyocytes
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    Verified Customer | Posted 12/10/2018
    HL-1 cardiomyocytes were pre-incubated with AMG 853 (1 µM, 30 min) followed by treatment with 15d-PGJ2 (15 µM, 30 min) to follow p38 activation using Western blot analysis. AMG 853 inhibited 15d-induced p38 phosphorylation.
    AMG 853 5701

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