Combretastatin A4

Name: Combretastatin A4
Brand: Tocris Bioscience
SKU: 1495

Tocris Bioscience | Catalog # 1495

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Citations (9)

Product Documents

Antiangiogenic

Discontinued Product

1495 has been discontinued. View all Microtubule Binding Compounds products.

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Antiangiogenic

Alternative Names

CRC 87-09,NSC 817373

View all Microtubule Binding Compounds »

Product Description

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Product Specifications for Combretastatin A4

Molecular Weight

316.35

Formula

C₁₈H₂₀O₅

Storage

Desiccate at -20°C

Purity

≥99%

Chemical Name

2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol

CAS Number

117048-59-6

PubChem ID

5351344

InChI Key

HVXBOLULGPECHP-WAYWQWQTSA-N

SMILES

OC1=CC(\C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.64	100
	Ethanol	31.64	100

Preparing Stock Solutions for Combretastatin A4

The following data is based on the product molecular weight 316.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.81 mL	31.61 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

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Mass

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Griggs Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 2001 PMID: 11562761
Lin Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17646428
Dorr Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 1996 PMID: 8913833

Product Documents for Combretastatin A4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Combretastatin A4

For research use only

Related Research Areas

Microtubules

Citations for Combretastatin A4

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