Desmocollin-2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-85711

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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Desmocollin-2 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Desmocollin-2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human colon, esophagus, liver and tonsil using Anti-DSC2 antibody NBP1-85711 (A) shows similar protein distribution across tissues to independent antibody NBP1-85710 (B).
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human colon shows moderate membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human tonsil shows strong membranous positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human esophagus shows strong membranous positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human liver shows weak membranous positivity in hepatocytes.
Desmocollin-2 Antibody - BSA Free Immunohistochemistry-Paraffin: Desmocollin-2 Antibody - BSA Free [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody - BSA Free [NBP1-85711]

Immunohistochemistry analysis in human esophagus and cerebral cortex tissues using HPA011911 antibody. Corresponding DSC2 RNA-seq data are presented for the same tissues.

Applications for Desmocollin-2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Desmocollin-2

Desmocollin 2 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Alternate Names

ARVD11, CDHF2, Desmocollin2, DG2, DSC2

Gene Symbol

DSC2

Additional Desmocollin-2 Products

Product Documents for Desmocollin-2 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Desmocollin-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cadherin Superfamily

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Desmocollin-2 Antibody - BSA Free

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  • Q: Does this antibody cross react with descmocollin-2 and descmocollin-3?

    A: According to UniProt, the gene DSC2 has two isoforms associated with it. Isoform 2A (canonical sequence) is also referred to as Desmocollin-2, and Isoform 2B is also referred to as Desmocollin-3. This is why we have it listed as an alternate name. The immunogen of the antibody is 100% homologous in both isoforms, so this antibody should recognize both Isoform 2A and 2B.

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