DRP1 Antibody (24GB8215)

Novus Biologicals | Catalog # NBP3-51854

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 24GB8215
View all DRP1 Primary Antibodies »

Product Specifications

Immunogen

Recombinant protein of human DRP1 (Uniprot: O00429)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Description

Reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Scientific Data Images for DRP1 Antibody (24GB8215)

DRP1 Antibody (24GB8215)

Immunocytochemistry/ Immunofluorescence: DRP1 Antibody (24GB8215)[NBP3-51854] -

Immunocytochemical staining of HepG2 cells with DRP1 antibody (1:500). Nuclei were stained blue with DAPI; Dynamin 1 like was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
DRP1 Antibody (24GB8215)

Flow Cytometry: DRP1 Antibody (24GB8215)[NBP3-51854] -

Flow cytometric analysis of DRP1expression in HepG2 cells using DRP1 antibody (1:1,000). Green, isotype control; red, Dynamin 1 like.
DRP1 Antibody (24GB8215)

Flow Cytometry: DRP1 Antibody (24GB8215)[NBP3-51854] -

Validation of DRP1 knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with DRP1 antibody (1:2,000) and analyzed using BD flow cytometer.

Applications for DRP1 Antibody (24GB8215)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DRP1

DRP1 is a member of the dynamin GTPase superfamily, which that contributes to mitochondrial division in mammalian cells. DRP1 plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses. Therefore, DRP1 provides a genetic tool to assess the role of mitochondria at synapses.

The DRP1 gene has 3 alternatively spliced transcripts encoding different isoforms, which are alternatively polyadenylated.

Long Name

Dynamin-1-like protein

Alternate Names

DLP1, DNM1L, DVLP, Dymple, HdynIV

Gene Symbol

DNM1L

Additional DRP1 Products

Product Documents for DRP1 Antibody (24GB8215)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for DRP1 Antibody (24GB8215)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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