Recombinant Exendin-4 Protein

Name: Recombinant Exendin-4 Protein
Brand: Novus Biologicals
SKU: NBP2-34945
Price: 500 USD
Availability: InStock

Novus Biologicals | Catalog # NBP2-34945

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Product Specifications
Scientific Data
Preparation & Storage
Calculators
Background
Product Documents
Specific Notices

Key Product Details

Source

E. coli

Applications

Bioactivity, SDS-PAGE

View all Exendin-4 Proteins and Enzymes »

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 39 amino acids corresponding to Exendin-4 Source: E. coli

Uniprot ID: P26349

Amino Acid Sequence: HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS

Purity

>95%, by SDS-PAGE and HPLC

Endotoxin Level

Less than 10 EU/mg of Exendin-4 as determined by LAL method.

Predicted Molecular Mass

4.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

1. Regulates Glucose levels rapidly;
2. Reduces Insulin resistance;
3. Reduces Glucagon;
4. Reduces HbA1c;
5. Stimulates beta cell growth which stimulates insulin production.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Exendin-4 Protein

SDS-PAGE: Recombinant Exendin-4 Protein [NBP2-34945]

SDS-Page: Recombinant Reptile Exendin-4 Protein [NBP2-34945] - Exendin-4 Protein [NBP2-34945]

Formulation, Preparation, and Storage

NBP2-34945

Formulation	Lyophilized from a 0.2 um filtered solution in PBS, pH 7.4.
Preservative	No Preservative
Concentration	Lyoph
Reconstitution	Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.
Format	Carrier-Free
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background: Exendin-4

Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53 % sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucosedependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes beta-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA sequence encoding the 39 amino acid of Exendin-4.

Alternate Names

Exendin4

Additional Exendin-4 Products

Product Documents for Recombinant Exendin-4 Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Exendin-4 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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