FGF acidic/FGF1, also known as ECGF and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF1 can translocate to the cytosol and to the nucleus. Intracellular FGF1 functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.
FGF acidic/FGF1 Antibody (C16) - BSA Free
Novus Biologicals | Catalog # NBP3-41078
Scientific images may be resized, cropped, or adjusted for brightness or contrast for presentation purposes. These updates are limited to presentation and do not affect the underlying scientific interpretation of the data. Where available, additional source data may be provided upon request.
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Key Product Details
Species Reactivity
Human, Mouse, Rat, Porcine
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # C16
Format
BSA Free
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Product Specifications
Immunogen
Immunized with recombinant Human FGF acidic/FGF1 (Uniprot#: P05230; Met1-Asp155 (Uniprot#: P05230)
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Scientific Data Images for FGF acidic/FGF1 Antibody (C16) - BSA Free
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] -
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] - Sample: Lane1: Rat Cerebrum lysate; Lane2: Rat Heart lysate; Lane3: Mouse Heart lysate; Lane4: Mouse Kidney lysate; Lane5: Porcine Heart lysate Primary Ab: 0.8ug/ml NBP3-41078; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] -
Western Blot: FGF acidic/FGF1 Antibody (C16) [NBP3-41078] - Sample: Lane1: Rat Cerebrum lysate; Lane2: Rat Heart lysate; Lane3: Mouse Heart lysate; Lane4: Mouse Kidney lysate; Lane5: Porcine Heart lysate Primary Ab: 0.8ug/ml NBP3-41078; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal AntibodyApplications for FGF acidic/FGF1 Antibody (C16) - BSA Free
Application
Recommended Usage
Western Blot
0.5-2ug/mL
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
0.01M PBS, pH7.4, 50% glycerol
Format
BSA Free
Preservative
0.05% Proclin 300
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: FGF acidic/FGF1
Long Name
Fibroblast Growth Factor acidic
Alternate Names
alpha-ECGF, beta-ECGF, FGF acidic, FGF-1, HBGF-1
Gene Symbol
FGF1
Additional FGF acidic/FGF1 Products
Product Documents for FGF acidic/FGF1 Antibody (C16) - BSA Free
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for FGF acidic/FGF1 Antibody (C16) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
- Cellular Response to Hypoxia Protocols
- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
- Western Blot Protocol for Cell Lysates
- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
- View all Protocols, Troubleshooting, Illustrated assays and Webinars
FAQs for FGF acidic/FGF1 Antibody (C16) - BSA Free
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Q: What is the heparin binding activity of FGF and VEGF?
A: These proteins are not assayed for their ability to bind Heparin. More information about the FGF family of growth factors is available in this review article: Basilico, C. (1992) Adv. Can. Res. 59:115.
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