FPR A14

Key Product Details

Product Description

Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC₅₀ values are 42 and 630 nM for neutrophil chemotaxis and Ca²⁺ mobilization respectively). Induces dose-dependent differentiation of mouse neuroblastoma N2a cells.

Product Specifications for FPR A14

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FPR A14

The following data is based on the product molecular weight 404.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Cussell The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 2019 PMID: 31170199
• Schepetkin High-throughput screening for small molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists. Mol.Pharmacol. 2007 PMID: 17229869

Product Documents for FPR A14