G10

Key Product Details

Product Description

G10 is an activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα and IFNγ gene expression in human fibroblasts. Exhibits no effect on NF-κB signaling. Blocks viral replication in vitro.

Product Specifications for G10

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for G10

The following data is based on the product molecular weight 430.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.60 mL	23.21 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sali Characterization of a novel human-specific STING agonist that elicits antiviral activity against emerging alphaviruses. PLoS Pathog. 2015 PMID: 26646986

Product Documents for G10