HKC54

Key Product Details

Product Description

HKC54 is a potent and selective TRPV2 covalent inhibitor (IC₅₀ = 0.4 μM). Displays 50-fold and 70-fold selectivity over TRPV1 and TRPA1, respectively. In vitro, inhibits cancer cell migration. In Balb/c mice, it suppresses metastasis in lung metastasis model of breast cancer.

Product Specifications for HKC54

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for HKC54

The following data is based on the product molecular weight 344.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.52 mL	29.04 mL
5 mM	0.58 mL	2.90 mL	5.81 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kiely-Collins Selective TRPV2 antagonists derived from the natural product piperlongumine inhibit cancer cell migration and metastasis. ACS Chem.Biol. 2026 PMID: 41879799

Product Documents for HKC54