Both BACE-1 and BACE-2 are membrane-bound aspartic proteases of the pepsin family. BACE-1 is a potential target for treatment of Alzheimer's disease because it is the principle b-secretase responsible for cleavage of amyloid precursor protein (APP). BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production.
Human BACE-1 (NP_036236.1) VersaClone cDNA
R&D Systems | Catalog # RDC3327
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Background: BACE-1
Long Name
beta-site Ayloid Precursor Protein Cleaving Enzyme 1
Alternate Names
BACE1
Gene Symbol
BACE1
UniProt
Additional BACE-1 Products
Product Documents for Human BACE-1 (NP_036236.1) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human BACE-1 (NP_036236.1) VersaClone cDNA
For research use only
Related Research Areas
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Associated Pathways
