Copeptin is a 39 amino acid glycosylated peptide that is a proteolytic product derived from a precursor which also contains Vasopressin and Neurophysin 2 peptides. The precursor protein is synthesized and cleaved in the hypothalamus before transport to the pituitary for storage and release. Copeptin is secreted in equimolar amounts with Vasopressin. It is more stable than Vasopressin and serves as a surrogate indicator of Vasopressin release. Vasopressin plays a major role in blood pressure regulation through control of water retention in the kidney and vascular tone. Serum levels of Copeptin are associated with metabolic syndrome, insulin resistance, sepsis, and heart dysfunction following myocardial infarction. Human Copeptin shares 79% sequence identity with mouse and rat Copeptin.
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Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Ala126-Gly140
Accession # P01185
Specificity
Clonality
Host
Isotype
Scientific Data Images for Human Copeptin Antibody (579021)
Detection of Human Copeptin by Western Blot.
Western blot shows lysates of human kidney (cortex) tissue and human kidney (medulla) tissue. PVDF Membrane was probed with 2 µg/mL of Mouse Anti-Human Copeptin Monoclonal Antibody (Catalog # MAB6077) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Copeptin at approximately 7-10 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.Applications for Human Copeptin Antibody (579021)
Western Blot
Sample: Human kidney (cortex) tissue and human kidney (medulla) tissue under non-reducing conditions only
Formulation, Preparation, and Storage
Purification
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculators
Background: Copeptin
Alternate Names
Entrez Gene IDs
Gene Symbol
UniProt
Additional Copeptin Products
Product Documents for Human Copeptin Antibody (579021)
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human Copeptin Antibody (579021)
For research use only
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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