IL-17C Antibody

Novus Biologicals | Catalog # NBP2-27100

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Bovine (94%), Canine (94%), Chimpanzee (100%), Equine (94%), Monkey (94%), Orangutan (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all IL-17C Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 80-130 from human IL-17C was used as the immunogen for this antibody.

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 89% homologous in Guinea pig, and 83% in Mouse, and Rat.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-17C Antibody

Western Blot: IL-17C Antibody [NBP2-27100]

Western Blot: IL-17C Antibody [NBP2-27100]

Western Blot: IL-17C Antibody [NBP2-27100] - Analysis of IL-17C using IL17C antibody. THP1 cell lysate in the 1) absence and 2) presence of immunizing peptide probed with 2 ug/ml of IL17C antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for IL-17C Antibody

Application
Recommended Usage

Western Blot

3-5ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-17C

IL-17C, also alternatively named IL-21, is a pro-inflammatory cytokine and member of the IL-17 family. The IL-17 family is comprised of at least six member, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F (1, 2). IL-17C, along with IL-17B, appears to stimulate release of TNF and IL-1 from the monocytic THP-1 cell line thus appearing to have a different receptor and induction pattern than IL-17A (1, 2). As a pro-inflammatory cytokine IL-17C augments the inflammatory process in arthritis models (2, 3). IL-17C is induced in epithelial cells by bacterial antigens and other inflammatory ligands such as imiquimod, exhibiting a direct linkage with innate immune receptors such as TLRs (2, 3). The IL-17C receptor complex appears to be comprised of IL-17RA or IL-17RE. Antibody to IL-17C allows further analysis of the unique regulatory activity, cellular receptors and cellular targets of IL-17C versus other members of the IL-17 family such as IL-17A. The study of IL-17C and its contribution to diseases caused by impaired epithelial barriers in autoimmune and inflammatory diseases such as psoriasis, asthma or inflammatory bowel disease potentiate development of new therapies directed at regulation of IL-17C or other IL-17 family members (4). The linkage of IL-17C with epithelial cells also furthers the study of the innate immune functions of epithelial cells.

Long Name

Interleukin 17C

Alternate Names

Cytokine CX2, IL17C

Gene Symbol

IL17C

UniProt

Q9P0M4

Additional IL-17C Products

Product Documents for IL-17C Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for IL-17C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Helper T (Th) Cells

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FAQs

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Associated Pathways

IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathway Thumbnail