Kv7.1 Antibody

Name: Kv7.1 Antibody
Brand: Novus Biologicals
SKU: NBP1-30119
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-30119

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Western Blot, Peptide ELISA, Control

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-EQLTVPRRGPDEGS corresponding to C-Terminus according to NP_861463.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_000209.2; NP_861463.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Kv7.1 Antibody

Western Blot: Kv7.1 Antibody [NBP1-30119]

Western Blot: Kv7.1 Antibody [NBP1-30119] - Analysis of Kv7.1 in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-30119 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Immunohistochemistry: Kv7.1 Antibody [NBP1-30119]

Immunohistochemistry: Kv7.1 Antibody [NBP1-30119] - (8ug/ml) staining of paraffin embedded Rat Liver. Heat induced antigen retrieval with citrate buffer Ph 6, HRP-staining.

Control: Kv7.1 Antibody [NBP1-30119] - Negative Control showing staining of paraffin embedded Rat Liver, with no primary antibody.

Applications for Kv7.1 Antibody

Application

Recommended Usage

Immunohistochemistry

6.0 - 8.0 ug/ml

Peptide ELISA

Detection limit 1:16000

Western Blot

1.0 - 3.0 ug/ml

Application Notes

WB: Approx. 60 kDa band observed in human heart lysates (calculated MW of 61.5 kDa band according to NP_861463.1). An additional band of unknown identity was also consistently observed at 28 kDa. This band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Kv7.1

This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).

Long Name

Potassium voltage-gated channel subfamily KQT member 1

Alternate Names

KCNA8, KCNA9, KCNQ1, KQT-like 1, KVLQT1

Entrez Gene IDs

3784 (Human); 16535 (Mouse); 84020 (Rat)

Gene Symbol

KCNQ1

UniProt

P51787 (Human)

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Product Specific Notices for Kv7.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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