Mouse Fetuin A, also known as alpha 2-Heremans-Schmid glycoprotein, is encoded by the AHSG gene. It has been also called "countertrypsin" because of its ability to inhibit trypsin (1). It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors (2, 3). It is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages (4). The major form of plasma Fetuin A corresponds to two disulfide bond-linked chains derived from the single chain (5). Fetuin-A has a number of functions. It is a negative acute-phase protein with normal circulating levels in adults (300‑600 μg/mL), which fall significantly (30‑50%) during injury and infection (5). It enhances entry of cationic inhibitors into macrophages (6). It inhibits both insulin receptor autophosphorylation and undesirable calcification (7, 8).
Mouse Fetuin A/AHSG Antibody (207432) [Biotin]
R&D Systems | Catalog # BAM15631
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Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Ala19-Ile345
Accession # P29699
Specificity
Clonality
Host
Isotype
Scientific Data Images for Mouse Fetuin A/AHSG Antibody (207432) [Biotin]
Mouse Fetuin A / AHSG ELISA Standard Curve
Recombinant Mouse Fetuin A/AHSG (Catalog # 1563-PI) was serially diluted and captured by Rat Anti-Mouse Fetuin A/AHSG Monoclonal Antibody (Catalog # MAB15632) coated on a Clear Polystyrene Microplate (Catalog # DY990). Rat Anti-Mouse Fetuin A/AHSG Biotinylated Monoclonal Antibody (Catalog # ) was incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)Applications for Mouse Fetuin A/AHSG Antibody (207432) [Biotin]
Mouse Fetuin A/AHSG Sandwich Immunoassay
Formulation, Preparation, and Storage
Purification
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculators
Background: Fetuin A/AHSG
References
- Yamamoto, K. and H. Sinohara (1993) J. Biol. Chem. 268:17750.
- Kellemann, J. et al. (1989) J. Biol. Chem. 264:14121.
- Dziegielewska, K.M. et al. (1990) J. Biol. Chem. 265:4354.
- Dziegielewska, K.M. et al. (1996) Histochem. Cell Biol. 106:319.
- Gejyo, F. and K. Schmid (1981) Biochim. Biophys. Acta 671:78.
- Wang, H. et al. (1998) Proc. Natl. Acad. Sci. USA 95:14429.
- Mathews, S.T. et al. (2000) Mol. Cell Endocrinol. 164:87.
- Schäfer, C. et al. (2003) J. Clin. Invest. 112:357.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional Fetuin A/AHSG Products
Product Documents for Mouse Fetuin A/AHSG Antibody (207432) [Biotin]
Certificate of Analysis
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Product Specific Notices for Mouse Fetuin A/AHSG Antibody (207432) [Biotin]
For research use only
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