RAR beta/NR1B2 Antibody

Novus Biologicals | Catalog # NBP1-81776

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Mouse (97%), Rat (97%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all RAR beta/NR1B2 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RAR beta/NR1B2 Antibody

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776] - Analysis in human placenta and pancreas tissues using NBP1-81776 antibody. Corresponding RARB RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776] - Staining of human placenta shows strong nuclear positivity in trophoblastic cells.
Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776] - Staining of human pancreas shows weak nuclear positivity in exocrine glandular cells.
Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776]

Immunohistochemistry-Paraffin: RAR beta/NR1B2 Antibody [NBP1-81776] - Staining of human rectum shows strong nuclear positivity in glandular cells.
RAR beta/NR1B2 Antibody Immunohistochemistry: RAR beta/NR1B2 Antibody [RAR beta/NR1B2 Antibody]

Immunohistochemistry: RAR beta/NR1B2 Antibody [RAR beta/NR1B2 Antibody]

Staining of human cerebral cortex shows strong nuclear positivity in neurons.

Applications for RAR beta/NR1B2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RAR beta/NR1B2

Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters (1,2). Loss of RAR-beta expression and the accumulation of p53 and Ki67 proteins may help in the early identification of esophageal cancer in high-risk populations (3).

Long Name

Retinoic Acid Receptor, beta

Alternate Names

HAP, NR1B2, RARB, RRB2

Gene Symbol

RARB

Additional RAR beta/NR1B2 Products

Product Documents for RAR beta/NR1B2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for RAR beta/NR1B2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for RAR beta/NR1B2 Antibody

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for RAR beta/NR1B2 Antibody

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  • Q: I am planning to perform IHC staining of RARB on FFPE samples. I have found the reference "J Cutan Pathol 2009;36; 1141-1145" used an antibody from your company. Would you let me know any other references using the antibody for IHC staining of RARB?

    A:

    Unfortunately we are not aware of any other publication wherein our Retinoic Acid Receptor beta antibodies were cited for their use in IHC application. From our sales records, it looks like the researcher used catalog number NB200-323 in the publication you mentioned. Retinoic Acid Receptor beta antibody NB200-323 is our best selling product among this category and it has also been cited for its use in WB application by Yang et al. in Am J Physiol Renal Physiol. 2008 Jun;294(6):F1433-40. We have at least 7 primary antibody products to Retinoic Acid Receptor beta that have been validated for IHC-P application.. We stand behind the quality of our products and offer 100% guarantee for the applications/species mentioned on the datasheets. We are always there to help if you come up with any difficulties and yes, we provide replacements/refunds after troubleshooting a problem, if you do not get your desired outcome! Therefore, please let us know if you have any specific questions or concerns on the IHC-P application of our Retinoic Acid Receptor beta antibodies. You may contact us at technical@novusbio.com.

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