RO 4929097

Tocris Bioscience | Catalog # 8906

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells
Tocris Bioscience
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Key Product Details

Description

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells
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Product Description

RO 4929097 is a potent and selective γ-secretase inhibitor (IC50 = 4 nM), exhibiting over 100-fold selectivity against a panel of 75 different proteins. Inhibits cellular processing of Notch and Aβ40 (IC50 = 5 nM and 14 nM, respectively). In tumor cells, inhibition of Notch processing results in lowered expression of HES1. In multiple xenograft models, RO 4929097 displays antitumour effects with no associated body weight loss or Notch-related toxicities. In melanoma cell lines, it inhibits tumor formation and blocks invasive growth pattern of metastatic melanoma. Can also be used to induce differentiation of iEM cells into luminal cells. Orally bioavailable.

Product Specifications for RO 4929097

Formula

C22H20F5N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide

CAS Number

847925-91-1

PubChem ID

49867930

InChI Key

OJPLJFIFUQPSJR-INIZCTEOSA-N

SMILES

O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 23.47mg/ml in DMSO and to 23.47mg/ml in Ethanol

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Background References

References are publications that support the biological activity of the product.

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Product Documents for RO 4929097

Certificate of Analysis

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Product Specific Notices for RO 4929097

For research use only

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