SAG

Tocris Bioscience | Catalog # TB4366-RMU

SAG synthesized to Ancillary Material Grade
Tocris Bioscience
100% Guarantee

Key Product Details

Description

SAG synthesized to Ancillary Material Grade
View all Ancillary Material Grade Compounds »

Product Description

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

is an Ancillary Material Grade version of SAG (Cat. No. 4366). Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.

Find out more about our Ancillary Material Grade product range.

Product Specifications for SAG

Molecular Weight

490.06

Formula

C28H28ClN3OS

Storage

Store at -20°C (± 5°C)

Purity

≥98%

Chemical Name

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

CAS Number

912545-86-9

InChI Key

VFSUUTYAEQOIMW-UHFFFAOYSA-N

SMILES

ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for SAG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SAG

For research use only

Customer Reviews for SAG

There are currently no reviews for this product. Be the first to review SAG and earn rewards!

Have you used SAG?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 for a review with an image

$10/€7/£6/$10CAN/¥1110 for a review without an image

Submit a review
Amazon Gift Card