Recombinant Human Tryptase alpha/beta 1 His Protein

Novus Biologicals | Catalog # NBP2-61189

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Key Product Details

Source

Baculovirus

Accession Number

Q15661

Tag

His

Applications

SDS-PAGE
View all Tryptase alpha/beta-1 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 31-275 of Human TPSAB1

Source:Baculovirus

Amino Acid Sequence: IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKPHHHHH H

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Predicted Molecular Mass

28.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human Tryptase alpha/beta 1 His Protein

SDS-PAGE: Recombinant Human Tryptase alpha/beta 1 His Protein [NBP2-61189]

SDS-PAGE: Recombinant Human Tryptase alpha/beta 1 His Protein [NBP2-61189]

SDS-Page: Recombinant Human TPSAB1 Protein [NBP2-61189] - 15 % SDS-PAGE (3ug)

Formulation, Preparation, and Storage

NBP2-61189
Formulation PBS (pH 7.4), 20% glycerol
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tryptase alpha/beta-1

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Alternate Names

TPS2, TPSB2, Tryptase beta-2, Tryptase beta2, Tryptase-C

Gene Symbol

TPSAB1

UniProt

Q15661 (Human)

Additional Tryptase alpha/beta-1 Products

Product Documents for Recombinant Human Tryptase alpha/beta 1 His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human Tryptase alpha/beta 1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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