FBXW12 Proteins and Enzymes

FBXW12, also known as F-box/WD repeat-containing protein 12, has 3 isoforms, a 464 amino acid isoform that is 53 kDa, a 394 amino acid isoform that is 45 kDa and a 445 amino acid isoform that is 51 kDa; ubiquitously expressed, acts as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Little is currently known about this protein disease involvement or interaction with other proteins.