PSENEN Products

Gamma-secretase subunit PSENEN, also called PEN2 (Presenilin enhancer protein 2) is a 10 kDa member of the PEN2 family. Human PSENEN is 101 amino acids (aa) in length, and is a multipass transmembrane protein. Human PSENEN shares 96% aa sequence identity with mouse and rat PSENEN. Functionally, PSENEN is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.