7 results for "MAPK Inhibitors" in Products
MAPK Inhibitors
The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.
Upon activation, MAPK can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, ...
Selective inhibitor of p38 MAPK
| Alternate Names: | Adezmapimod |
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% |
Selective inhibitor of Mnk1
| Chemical Name: | N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine |
| Purity: | ≥98% |
Potent MK2 inhibitor
| Chemical Name: | (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk9; also inhibits MK2
| Chemical Name: | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
| Purity: | ≥98% |
Potent and selective Tpl2 (MAP3K8) inhibitor
| Chemical Name: | 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-quinolinecarbonitrile |
| Purity: | ≥98% |
Potent and selective TNNI3K inhibitor, orally bioavailable
| Chemical Name: | N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea |
| Purity: | ≥98% |
Potent and selective MAP4K1 (HPK1) inhibitor
| Chemical Name: | 5-Cyclopropyl-6-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-2-pyrazinecarboxamide |
| Purity: | ≥98% |
