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382 results for "TIMP-2" in Products
TIMP-2 Products
TIMP-2 (tissue inhibitor of metalloproteinases 2) is one of several TIMPs that form complexes with matrix metalloproteinases (MMPs) and inhibit their proteolytic activity. MMPs play an important role in many normal physiological processes such as embryonic development, morphogenesis, reproduction and tissue remodeling. They also participate in many pathological processes such as arthritis, cancer and cardiovascular disease. TIMP-2 binding to pro-MMP-2 is essential for the cell surface activation of pro-MMP-2 by active MMP-14 (MT1-MMP). TIMP-2 also suppresses EGF-mediated mitogenic signaling by short-circuiting EGF R activation.
| Reactivity: | Human |
| Sensitivity: | 0.064 ng/mL |
| Assay Range: | 0.156-10 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva, Urine) |
| Applications: | ELISA |
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| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #89025 |
| Applications: | IHC, WB |
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| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | KO, IHC, WB, B/N, Dual ISH-IHC |
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| Reactivity: | Human |
| Applications: | Simple Plex |
| Reactivity: | Human |
| Assay Range: | 31.2-2000 pg/mL |
| Applications: | ELISA |
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| Reactivity: | Human |
| Source: | CHO |
| Accession #: | P16035 |
| Applications: | Inhibition Activity |
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| Reactivity: | Mouse |
| Assay Range: | 7.81-500 pg/mL |
| Applications: | ELISA |
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| Reactivity: | Human, Mouse, Rat, Canine, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1A6 |
| Applications: | IHC, WB, Flow |
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| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #127711 |
| Applications: | KO, ELISA(Cap) |
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| Reactivity: | Human, Mouse, Rat, Canine, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1A6 |
| Applications: | IHC, WB, Flow, CyTOF-ready |
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| Reactivity: | Human, Mouse, Rat, Bovine, Guinea Pig, +2 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SPM356 |
| Applications: | IHC, WB, Flow, ICC/IF, CyTOF-ready |
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| Reactivity: | Mouse |
| Source: | NS0 |
| Accession #: | NP_035724 |
| Applications: | Enzyme Activity |
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| Reactivity: | Human |
| Source: | CHO |
| Applications: | WB |
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| Reactivity: | Human |
| Details: | Goat IgG Monoclonal Clone #40019A |
| Applications: | KO, IHC, WB |
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| Reactivity: | Human, Mouse, Rat, Bovine, Guinea Pig, +2 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #3A4 |
| Applications: | IHC, WB, Flow, ICC/IF |
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| Reactivity: | Human, Mouse, Rat, Bovine, Guinea Pig, +2 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SPM356 |
| Applications: | IHC, WB, Flow, ICC/IF |
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| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #F27 P3 A4 |
| Applications: | IHC, WB, ICC/IF |
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| Reactivity: | Human, Mouse, Rat, Bovine, Guinea Pig, +2 More |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #3A4 |
| Applications: | IHC, WB, Flow, ICC/IF, CyTOF-ready |
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| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA(Det) |
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| Reactivity: | Human, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #3A4 |
| Applications: | IHC, WB |
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| Reactivity: | Human, Mouse, Porcine, Chicken, Rabbit, +1 More |
| Details: | Mouse IgG2A Monoclonal Clone #3A4 |
| Applications: | IHC, WB, ELISA |
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| Reactivity: | Human, Non-human Primate |
| Applications: | Ctrl, Simple Plex |
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| Reactivity: | Human |
| Applications: | ELISA, Ctrl |
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| Reactivity: | Human, Mouse, Rat, Bovine, Guinea Pig, +2 More |
| Details: | Rabbit IgG Monoclonal Clone #TIMP2/2488R |
| Applications: | IHC |
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| Reactivity: | Non-human Primate |
| Applications: | Simple Plex |